Cannabinoid Receptor
Cannabinoid Receptor
Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.
Cannabinoid Receptor Isoform Specific Products
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Cannabinoid Receptor Inhibitors
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Cannabinoid Receptor Agonists
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Cannabinoid Receptor Antagonists
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Cannabinoid Receptor Activators
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Cannabinoid Receptor Modulators
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Cannabinoid Receptor Chemical
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Cannabinoid Receptor Inducer
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Cannabinoid Receptor Degrader
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Cannabinoid Receptor Controls
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Cannabinoid Receptor Ligands
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Cannabinoid Receptor Related Products (449)
Related Products (449)
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Antibodies (1)
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Cannabinoid Receptor Isoform Comparison
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CB1/2 receptor-1
0 ImagesCat. No.: HY-164817CAS No.: 1260669-31-5CB1/2 receptor-1 (compound 5.3) is a CB1/2 receptor agonist. CB1/2 receptor-1 can be used in angiogenesis research.
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GW 833972A free base
0 ImagesCat. No.: HY-180365CAS No.: 667905-37-5GW 833972A free base is a selective CB₂ receptor agonist with pEC₅₀ of the human CB₂ receptor for GW 833972A free base of 7.3, and its selectivity for the CB₂ receptor is approximately 1000 times higher than that for the CB₁ receptor. GW 833972A free base inhibits induced neuronal depolarization and suppresses coughing caused by citric acid in guinea pig models. GW 833972A free base can be used for the study of chronic cough.
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CB2 receptor agonist 4
0 ImagesCat. No.: HY-153693CAS No.: 2052602-31-8CB2 receptor agonist 4 (Compound 8) is a highly selective cannabinoid receptor type 2 (CB2 Receptor) agonist with an EC50 of 13.99 nM. CB2 receptor agonist 4 shows no significant activity against cannabinoid receptor type 1. CB2 receptor agonist 4 can be used for the research of pain and immune-related diseases.
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2-Linoleoyl glycerol-d5
0 ImagesCat. No.: HY-W770198Synonyms: 2-Monolinolein-d5; 2-Monolinoleoylglycerol-d52-Linoleoyl glycerol-d5 (2-Monolinolein-d5; 2-Monolinoleoylglycerol-d5) is the deuterium labeled 2-Linoleoyl glycerol (HY-130311). 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG).
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CBR Agonist-2
0 ImagesCat. No.: HY-151107CBR Agonist-2 is a CB1 agonist (CB1R; CB1 ligand) with an EC50 and a Ki of 960 nM and 970 nM, respectively. CBR Agonist-2 is a promising tool for investigating the involvement of hCB1R in disorders associated with the endocannabinoid system.
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IDFP
0 ImagesCat. No.: HY-121637CAS No.: 615250-02-7Synonyms: iso-PrdodecylfluorophosphonateIDFP (iso-Prdodecylfluorophosphonate) is a chemical affinity probe for the cannabinoid CB1 receptor.
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CB2R ligand-1
0 ImagesCat. No.: HY-175730CAS No.: 2816933-22-7CB2R ligand-1 (Compound L14) is a selective Cannabinoid type 2 receptor (CB2R) ligand with a with Ki of 0.16 nM for CB2R over CB1R. CB2R ligand-1 as be used as a tracer for positron emission tomography (PET) imaging of neurodegenerative diseases, inflammation and cancer.
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1'-Naphthoyl-2-methylindole
0 ImagesCat. No.: HY-121947CAS No.: 80749-33-31'-Naphthoyl-2-methylindole (Compound 88) is a cannabinoid mimetics and an inhibitor for Win 55212-2, that inhibits 34% of [3H]Win 55212-2 binding to cannabinoid receptors at 3 μM.
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RD-pepcan-11
0 ImagesCat. No.: HY-P11831RD-pepcan-11 is a CB1 receptor agonist. RD-pepcan-11 increases the relative phosphorylation level of ERK1/2. RD-pepcan-11 mediates analgesic effects through interaction with CB1 receptors in a carrageenan-induced mouse inflammatory pain model. RD-pepcan-11 can be used in studies related to inflammatory pain.
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15(S)-HETE Ethanolamide
0 ImagesCat. No.: HY-130357CAS No.: 161744-53-215(S)-HETE Ethanolamide is a cannabinoid analog the CB1 receptor (Ki of 600 nM).
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Anandamide-15N
0 ImagesCat. No.: HY-10863S2Purity: 99.78%Synonyms: AEA-15NN; Arachidonoyl ethanolamide-15NNAnandamide-15N (AEA-15N) is the 15N-labeled Anandamide (HY-10863). Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis.
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MDMB-FUBICA
0 ImagesCat. No.: HY-168750CAS No.: 1971007-91-6MDMB-FUBICA is a potent agonist of the cannabinoid receptors with psychoactive properties. MDMB-FUBICA can be used in the study of electronic cigarette.
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BI-5756
0 ImagesCat. No.: HY-171883CAS No.: 1332485-18-3BI-5756 is a CETP inhibitor and cannabinoid receptor 1 (CB1) agonist. BI-5756 can significantly increase HDL-C levels and reduce LDL-C levels. BI-5756 can also enhance the function of regulatory T cells while maintaining T cell-mediated anti-tumor activity. BI-5756 can directly inhibit the growth of tumor cells and upregulate the expression of MHC I, MHC II, and CD80 on tumor cells. BI-5756 has a protective effect in graft-versus-host disease models. BI-5756 can be used in research on tumors, graft-versus-host disease, and metabolic diseases.
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CB2R probe 1
0 ImagesCat. No.: HY-147532CAS No.: 2634714-79-5CB2R probe 1 is a safe and green CB2R (cannabinoid 2 receptor) fluorescent probe with an Ki of 130 nM. CB2R probe 1 shows low cytotoxicity in cancer cells.
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(R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide
0 ImagesCat. No.: HY-115428CAS No.: 220556-74-1(R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide (Compound 19) is the analogue of endogenous cannabinoid receptor ligand Anandamide (HY-10863). (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide shows weak binding affinity for CB1 and CB2 with Kis of both 21 μM.
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CB1R antagonist 2
0 ImagesCat. No.: HY-172409CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056)-induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models.
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Hemopressin(human, mouse) TFA
0 ImagesCat. No.: HY-P1091ACAS No.: 1431329-48-4Hemopressin TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin TFA exerts antinociceptive action in inflammatory pain models.
